It’s 19,996x more powerful then vitamin C at antioxidant reactions~ That should detox some shit!
Your made from Pyrroquilone quinone it’s found in dirt, Mother’s milk and stardust!! So cool! I was researching the most potent detoxifier for our times and found this!
“PQQ is a component of interstellar dust (or cometary grains) and raises the question of PQQ’s evolutionary importance to simpler life forms.1 In bacteria, PQQ stimulates growth and serves as a cofactor for a special class of dehydrogenases/oxidoreductases. As such, PQQ is a key regulator of cellular function and is involved in signal transduction processes involved in cellular growth, development, differentiation and survival.” Murray ND 2011*
So PQQ alone KILLS vitamin C in redoxing, what’s that? It’s when a compound can add an Oxygen to prevent oxidation, aging, dying, detox & cancer preventing, depends on the cell. A vitamin C particle can redox 4 chemical reactions. A PQQ molecule can redox 20,000!!!
Here are some of the effects noted in the animal studies:
• PQQ reverses cognitive impairment caused by chronic oxidative stress and improves performance on memory tests in animal models.1,9
• PQQ supplementation stimulates the production and release of nerve growth factor.1,10
• PQQ protects against the self-oxidation of the DJ-1 gene, an early step in the onset of Parkinson’s disease.1,11
• PQQ protects brain cells against oxidative damage following ischemia-reperfusion injury.1,12
• PQQ blocks the formation of inducible nitric oxide synthase (iNOS), a major source of reactive nitrogen species (RNS) that are so damaging to neurons.1,13
• PQQ protects against the likelihood of severe stroke in an experimental animal model for stroke and brain hypoxia.1,14
• PQQ protects the brain against neurotoxicity induced by other powerful toxins, including mercury, glutamate and oxidopamine (a potent neurotoxin used by scientists to induce Parkinsonism in laboratory animals by destroying dopaminergic and noradrenergic neurons).1,15,16
• PQQ prevents development of alpha-synuclein, a protein associated with Parkinson’s disease.1,17
• PQQ also protects nerve cells from the oxidizing ravages of the beta-amyloid-protein linked with Alzheimer’s disease.1,18
I’m sure they are using this in many human trials. I can gather why not too many are released yet. $$$$
We have redox cell signaling molecules and PQQ based enhancement products around for the last decade. Numerous athletes do know about this, Ugh wish that was me sometimes, Athlete in a Marfan body…doesn’t do well. But i’ll add this now and see how much more Kung fu I can do!!
Can we truly defy aging with this? Possibly?? LOL Look forward to healing you and hearing your stories! I have numerous patient’s with Alzhiemer patient’s , nerve pain, cognitive impairment to toxin overloaded patient’s. I’ll keep you updated on! I’d love to help you out! I’m using Mito PQQ by. Designs for Health. Let me know how it does for you.
I’m hoping for optimal brain function, prevent endocrine disruptors thus better performance from all my systems and detox this world out!
I first read Dr Micheal Murray’s ND article from 2011 when researching this compound. He put together most of these researched benefits. Read more at *https://bioclinicnaturals.com/wp-content/uploads/2016/06/PQ.pdf
Mother Nature has food sources of PQQ, besides dirt and breast milk. Apparantly even the Coke they tested! yes i believe that is the beverage not the pharmaceutical. 🙂
FOODS with PQQ. ***Denote the highest levels ** second highest *second lowest
Fermented soybeans (natto)*
Miso (bean paste)
Tofu (bean curd)***
1. Rucker R., Chowanadisai W., Nakano M., “Potential physiological importance of pyrroloquinoline quinone,” Altern Med Rev, 2009 Sep; 14(3): 268-77.
2. Kumazawa T., Sato K., Seno H., et al., “Levels of pyrroloquinoline quinone in various foods,” Biochem J, 1995; 307: 331-333.
3. Paz M.A., Martin P., Fluckiger R., et al., “The catalysis of redox cycling by pyrroloquinoline quinone (PQQ), PQQ derivatives, and isomers and the specificity of inhibitors,” Anal Biochem, 1996; 238: 145-149.
4. Kasahara T., Kato T., “Nutritional biochemistry: a new redox-cofactor vitamin for mammals,” Nature, 2003; 422: 832.
5. Steinberg F., Stites T.E., Anderson P., et al., “Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets,” Exp Biol Med (Maywood), 2003; 228: 160-166.
6. Chowanadisai W., Bauerly K.A., Tchaparian E., et al., “Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression,” Journal of Biological Chemistry, 2010; 285(1): 142-52. 7. Stites T., Storms D., Bauerly K., et al., “Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice,“ J Nutr, 2006; 136: 390-396.
8. Chowanadisai W., Bauerly K., Tchaparian E., et al., “Pyrroloquinoline quinone (PQQ) stimulates mitochondrial biogenesis,” FASEB J, 2007; 21: 854.
9. Ohwada K., Takeda H., Yamazaki M., et al., “Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats,” J Clin Biochem Nutr, 2008; 42: 29-34.
10. Yamaguchi K., Sasano A., Urakami T., Tsuji T., Kondo K., “Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo,” Biosci Biotechnol Biochem, 1993 Jul; 57(7): 1231-3.
11. Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H., “Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1,” Biol Pharm Bull, 2008 Jul; 31(7): 1321-6.
12. Zhang Y., Feustel P.J., Kimelberg H.K., “Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat,” Brain Res, 2006; 1094: 200-206.
13. Hirakawa A., Shimizu K., Fukumitsu H., Furukawa S., “Pyrroloquinoline quinone attenuates iNOS gene expression in the injured spinal cord,” Biochem Biophys Res Commun, 2009; 378: 308-312.
14. Jensen F.E., Gardner G.J., Williams A.P., et al., “The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury,” Neuroscience, 1994; 62: 399-406.
15. Zhang P., Xu Y., Sun J., et al., “Protection of pyrroloquinoline quinone against methylmercury-induced neurotoxicity via reducing oxidative stress,” Free Radic Res, 2009; 43: 224-233.
16. Zhang Q., Shen M., Ding M., Shen D., Ding F., “The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway,” Toxicol Appl Pharmacol, 2011 Apr 1; 252(1): 62-72.
17. Kim J., Harada R., Kobayashi M., Kobayashi N., Sode K., “The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alphasynuclein,” Mol Neurodegener, 2010 May 20; 5: 20.
18. Kim J., Kobayashi M., Fukuda M., et al., “Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins,” Prion, 2010 Jan; 4(1): 26-31.
19. Nakano M., Ubukata K., Yamamoto T., Yamaguchi H., “Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons,” FOOD Style, 2009; 21: 13(7): 50-3.
20. http://pyrroloquinoline-quinone.com/pqq-info/ accessed 4/21/2011.